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1. 基(ji)本信(xin)息
品系名称：B6-Tigitem1(hTigit)Vst/Vst
常用名：C57BL/6-Tigit人源化小鼠; Tigit人源化小鼠;Hu-Tigit
背景：C57BL/6NCrl
毛色：黑色
品系建立：
采用CRISPR-Cas9辅助的方法，将小鼠(shu)Tigit基因(yin)(T Cell Immunoreceptor With Ig And ITIM Domains)替换(huan)为人(ren)源(yuan)Tigit。这样在(zai)Tigit人(ren)源(yuan)化小鼠(shu)体内，使用人(ren)源(yuan)Tigit抗体抑(yi)制(zhi)剂时(shi)就(jiu)可(ke)以识(shi)别，进行相(xiang)关的药(yao)效或药(yao)物(wu)筛选实(shi)验(yan)。
2. 应用领(ling)域
-人源化和(he)癌症(zheng)治(zhi)疗
-免(mian)疫治疗
-药物筛(shai)选
3. 参考文献(xian)
（1）The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.Yu X, Harden K, Gonzalez LC, Francesco M, Chiang E, Irving B, Tom I, Ivelja S, Refino CJ, Clark H, Eaton D, Grogan JL.Nat Immunol. 2009 Jan;10(1):48-57. doi: 10.1038/ni.1674. Epub 2008 Nov 16.
（2）Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering.Stengel KF, Harden-Bowles K, Yu X, Rouge L, Yin J, Comps-Agrar L, Wiesmann C, Bazan JF, Eaton DL, Grogan JL.Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5399-404. doi: 10.1073/pnas.1120606109. Epub 2012 Mar 15.
